Work Packages

Work package 1 – Management of the work
Work package 2 – External communication and dissemination and interaction with pertinent initiatives and institutions
Work package 3 – Develop methods to assess effectiveness, economic, ethical, socio-cultural, and legal issues

Work package 4 – Develop methods to identify moderators of effects and preferences related to individual patients

The key concept in work package 4 is heterogeneity, the phenomenon that patients respond differently to medical treatments. It means that we cannot limit an evaluation of a health care technology to the question whether it works; we should also address the question: for whom? Can we identify particular characteristics of patients that are predictive of treatment outcome? And can we use this information in order to distinguish patients who truly benefit from treatment from those who are unlikely to benefit? The aims are to develop search strategies that can be used to retrieve studies reporting such prognostic information and to develop tools that can be used to appraise their quality. In addition, we will identify tools that can be used to assess how patients value specific treatment outcomes. Using this type of information (prognostic factors and valuation of treatment outcomes) should facilitate selection of treatments that are most likely to benefit each individual patient (‘personalised medicine’).

Lead partner: Radboud University Medical Centre

Work package 5 – Develop methods to include context, setting, and implementation in the assessment of complex technologies
Work package 6 – Develop a method for integrating the different issues
Work package 7 – Case Study: A patient-centered, comprehensive, and integrated HTA on specialist palliative care
Work package 8 – Applicability and relevance of the products for broader application